TMG (Trimethylglycine / Betaine Anhydrous)
Methyl donor that supports homocysteine metabolism and methylation. Essential for those on NAD+ therapy or with MTHFR variants.
Amino AcidsMorningStrong Evidence
Mechanism of Action
TMG donates methyl groups to recycle homocysteine back to methionine, bypassing the folate-dependent pathway. Supports SAMe production, liver function, and is critical for those depleting methyl reserves through NAD+ supplementation.
Dosing
- Recommended Range
- 1000-3000 mg
- Optimal Timing
- Morning
- Evidence Level
- Strong
Safety Information
Interactions
- Works synergistically with B12 and folate
- May enhance NAD+ therapy effectiveness
Contraindications
- May increase TMAO in some individuals
- Monitor if you have kidney concerns
Comprehensive Information
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Key Benefits
Natural Food Sources
Optimal Timing & Absorption
Signs of Deficiency
Synergistic Supplements
Practical Tips
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